期刊
JOURNAL OF MAGNETIC RESONANCE
卷 241, 期 -, 页码 60-73出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2013.11.014
关键词
Non-uniform sampling; Protein backbone chemical shift assignments; Maximum entropy reconstruction; Iterative soft threshold reconstruction; Reduced time multidimensional NMR spectroscopy
资金
- National Institute of Health [GM047467, EB002026, NIDDKK01-DK085198]
Multi-dimensional NMR spectra have traditionally been processed with the fast Fourier transformation (FFT). The availability of high field instruments, the complexity of spectra of large proteins, the narrow signal dispersion of some unstructured proteins, and the time needed to record the necessary increments in the indirect dimensions to exploit the resolution of the highfield instruments make this traditional approach unsatisfactory. New procedures need to be developed beyond uniform sampling of the indirect dimensions and reconstruction methods other than the straight FFT are necessary. Here we discuss approaches of non-uniform sampling (NUS) and suitable reconstruction methods. We expect that such methods will become standard for multi-dimensional NMR data acquisition with complex biological macromolecules and will dramatically enhance the power of modern biological NMR. (c) 2013 Elsevier Inc. All rights reserved.
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