期刊
JOURNAL OF MAGNETIC RESONANCE
卷 197, 期 1, 页码 100-106出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2008.12.004
关键词
DNP; Hyperpolarized C-13 MR metabolic imaging; H-1 decoupling; T1; Clinical MR system
资金
- NIH [R01 EB007588]
Application of C-13 MRS in vivo on whole body MR system has been limited due to the low static field (and consequent low signal to noise ratio-SNR) of these scanners; thus there have been few reports of H-1 decoupled C-13 MRS in vivo using a clinical MR platform. The recent development of techniques to retain highly polarized spins in Solution following DNP in a solid matrix has provided a mechanism to use endogenous pre-polarized C-13 labeled Substrates to study real time cellular metabolism in vivo with high SNR. In a recent in vivo hyperpolarized metabolic imaging Study using C-13 pyruvate, it has been demonstrated that the line shape (signal decay) of the resonances observed are greatly affected by J(CH), coupling in addition to inhomogeneous broadening. This study demonstrates the feasibility of improving hyperpolarized C-13 metabolic imaging in vivo by incorporating H-1 decoupling on a clinical whole body 3 T MR scanner. No reduction of T1 of a pre-polarized C-13 substrate ([1-C-13] lactate) in Solution was observed when H-1 decoupling was applied with WALTZ16 sequence. Narrower linewidth for the [1-C-13] lactate resonance was observed in hyperpolarized C-13 MRSI data in vivo with H-1 decoupling. (C) 2008 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据