期刊
JOURNAL OF MAGNETIC RESONANCE
卷 199, 期 1, 页码 25-29出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2009.03.008
关键词
Atomic magnetometers; Zero-field NMR; Microfluidics; Scalar coupling
资金
- ONR-MURI [FD-N00014-05-1-0406]
- US Department of Energy [DE-AC03-76SF00098]
- Microsystems Technology Office of the Defence Advanced Research Projects Agency (DARPA)
Scalar couplings of the form JI(1) . I(2) between nuclei impart valuable information about molecular structure to nuclear magnetic-resonance spectra. Here we demonstrate direct detection of J-spectra due to both heteronuclear and homonuclear J-coupling in a zero-field environment where the Zeeman interaction is completely absent. We show that characteristic functional groups exhibit distinct spectra with straightforward interpretation for chemical identification. Detection is performed with a microfabricated optical atomic magnetometer, providing high sensitivity to samples of microliter volumes. We obtain 0.1 Hz linewidths and measure scalar-coupling parameters with 4-mHz statistical uncertainty. We anticipate that the technique described here will provide a new modality for high-precision J spectroscopy using small samples oil microchip devices for multiplexed Screening, assaying, and sample identification in chemistry and biomedicine. (C) 2009 Elsevier Inc. All rights reserved.
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