期刊
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
卷 51, 期 7, 页码 547-556出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10601325.2014.916175
关键词
Arsenic polyesters; antimony polyesters; bismuth polyesters; pancreatic cancer; breast cancer; prostate cancer; MALDI MS; interfacial polycondensation
The interfacial condensation between the salt of thiodiglycolic acid and the Group V dihalides produces the corresponding polyesters in moderate to good yield in 15 secs and less. The products are tacky to glassy. Infrared spectroscopy shows the formation of the M-O linkage with bands present derived from both reactants. The geometry about the metal is predominately non-bridging. MALDI MS shows ion fragment clusters to two repeat units with ion fragment clusters consistent with the formation of the M-O-C(O)- linkage. The arsenic polymer exhibits outstanding inhibition of the AsPC-1 adenocarcinoma pancreatic cancer cell line. Both the arsenic and antimony polymer show good inhibition of the PC-3 prostate cancer cell line. The antimony polymer shows good inhibition of both the MDA-MB-231 breast cancer cells that are estrogen-independent and estrogen receptor negative and the MCF-7 breast cancer cells that are an estrogen receptor (ER) positive cancer cell line.
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