期刊
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
卷 45, 期 9, 页码 776-784出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10601320802223242
关键词
drug delivery devices; hydrogels; molecular imprinted polymers; release dynamics; swelling kinetics
In view of technological significance of molecular imprinting polymers in drug delivery, the present study is an attempt to synthesize 2-hydroxyethylmetacrylate (HEMA) and acrylic acid (AAc) based hydrogels imprinted with model drug glucose. Both molecular imprinted polymers (MIPs) and non-imprinted polymers (NIPs) have been synthesized and have been used to study their binding affinity, swelling and in vitro release dynamics of the drug. It has been observed from this study that the template formed in MIPs has increased the absorption percentage of the drug and has improved the release profile of the drug from these polymers.
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