SPECIATION OF SELENIUM IN BIOLOGICAL SAMPLES BY ION CHROMATOGRAPHY WITH INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY

A comprehensive review is presented addressing recent trends in the speciation and determination of selenium in biological sample matrices, including important analytical aspects such as sample clean up, pre-concentration, method development, and removal of instrumental interferences. A brief outline of analytical principles, together with an overview of the recent developments and applications of selenium speciation determination is included. The newer methods for detecting selenium, including preparation schemes are also discussed together with speciation methodology based on ion chromatography hyphenated with inductively coupled plasma mass spectrometric techniques.