期刊
JOURNAL OF LIPOSOME RESEARCH
卷 25, 期 1, 页码 32-37出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/08982104.2014.924140
关键词
Homogenization; niosome; size; sonication; zeta potential
In this study, a niosome nanodispersion was manufactured using high-pressure homogenization following the hydration of proniosomes. Using beclometasone dipropionate (BDP) as a model drug, the characteristics of the homogenized niosomes were compared with vesicles prepared via the conventional approach of probe-sonication. Particle size, zeta potential, and the drug entrapment efficiency were similar for both size reduction mechanisms. However, high-pressure homogenization was much more efficient than sonication in terms of homogenization output rate, avoidance of sample contamination, offering a greater potential for a large-scale manufacturing of noisome nanodispersions. For example, high-pressure homogenization was capable of producing small size niosomes (209 nm) using a short singlestep of size reduction (6 min) as compared with the time-consuming process of sonication (237nm in >18 min) and the BDP entrapment efficiency was 29.65% +/- 4.04 and 36.4% +/- 2.8. In addition, for homogenization, the output rate of the high-pressure homogenization was 10 ml/min compared with 0.83 ml/ min using the sonication protocol. In conclusion, a facile, applicable, and highly efficient approach for preparing niosome nanodispersions has been established using proniosome technology and high-pressure homogenization.
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