期刊
JOURNAL OF LIPOSOME RESEARCH
卷 18, 期 3, 页码 195-209出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/08982100802309552
关键词
anaphylatoxin; anaphylaxis; antibody; C1q; complement system; ELISA; liposome; membrane attack complex; serum
The complement system is one of the most ancient defense strategies, which serves as an important effector arm of both innate and acquired immunity. Three consequences ensue when liposomes trigger the complement system in the blood. These are priming of the vesicular surface by opsonic complement fragments for recognition and clearance by phagocytic cells, generation of anaphylatoxins, and chemoattractants, which may subsequently initiate pseudoallergy-related anaphylaxis in sensitive individuals, and insertion of the lytic complex C5b-9 into the liposomal bilayer, which may result in substantial leakage of vesicular encapsulated aqueous cargo. Here, we briefly review and discuss the molecular basis of complement activation by phospholipid vesicles and reflect on sensitive and rapid Enzyme-Linked Immunosorbent Assays (ELISA) for assessing and monitoring liposome-mediated triggering of a complement cascade in human serum.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据