4.6 Review

Thematic Review Series: New Lipid and Lipoprotein Targets for the Treatment of Cardiometabolic Diseases Niacin, an old drug with a new twist

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When Clinical Trials Fail to Address Treatment Gaps: The Failure of Niacin-Laropiprant to Reduce Cardiovascular Events

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Role of prostaglandin D2 and the autonomic nervous system in niacin-induced flushing

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Statins and Risk of New-Onset Diabetes Mellitus

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Niacin and biosynthesis of PGD2 by platelet COX-1 in mice and humans

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Extended-release niacin/laropiprant lipid-altering consistency across patient subgroups

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Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells

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Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy

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Seeing red: flushing out instigators of niacin-associated skin toxicity

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Niacin stimulates adiponectin secretion through the GPR109A receptor

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Extended-Release Niacin or Ezetimibe and Carotid Intima-Media Thickness

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Effects of laropiprant on nicotinic acid-induced flushing in patients with dyslipidemia

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Preferential increase in high-molecular weight adiponectin after niacin

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Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans

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GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing

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New perspectives on the use of niacin in the treatment of lipid disorders

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Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells

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Lipoprotein(a) An elusive cardiovascular risk factor

L Berglund et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2004)

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Pyrazole derivatives as partial Agonists for the nicotinic acid receptor

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Molecular identification of nicotinic acid receptor

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Molecular identification of high and low affinity receptors for nicotinic acid

A Wise et al.

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PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect

S Tunaru et al.

NATURE MEDICINE (2003)

Article Medicine, General & Internal

Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease

BG Brown et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)

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Lipoprotein(a) and coronary heart disease - Meta-analysis of prospective studies

J Danesh et al.

CIRCULATION (2000)