期刊
JOURNAL OF LIPID RESEARCH
卷 54, 期 7, 页码 1884-1893出版社
ELSEVIER
DOI: 10.1194/jlr.M036640
关键词
apolipoprotein B; antioxidative property; low density lipoprotein; high density lipoprotein
资金
- Taishan Scholars Foundation of Shandong Province [zd056, zd057]
- special research funding of Taishan Medical University
- National Natural Science Foundation of China [81200216]
- Promotive Research Fund for Excellent Young and Middle-aged Scientists of Shandong Province [BS2012YY034]
We have found that hydrogen (dihydrogen; H-2) has beneficial lipid-lowering effects in high-fat diet-fed Syrian golden hamsters. The objective of this study was to characterize the effects of H-2-rich water (0.9-1.0 l/day) on the content, composition, and biological activities of serum lipoproteins on 20 patients with potential metabolic syndrome. Serum analysis showed that consumption of H-2-rich water for 10 weeks resulted in decreased serum total-cholesterol (TC) and LDL-cholesterol (LDL-C) levels. Western blot analysis revealed a marked decrease of apolipoprotein (apo)B100 and apoE in serum. In addition, we found H-2 significantly improved HDL functionality assessed in four independent ways, namely, i) protection against LDL oxidation, ii) inhibition of tumor necrosis factor (TNF)-alpha-induced monocyte adhesion to endothelial cells, iii) stimulation of cholesterol efflux from macrophage foam cells, and iv) protection of endothelial cells from TNF-alpha-induced apoptosis. Further, we found consumption of H-2-rich water resulted in an increase in antioxidant enzyme superoxide dismutase and a decrease in thiobarbituric acid-reactive substances in whole serum and LDL. In conclusion, supplementation with H-2-rich water seems to decrease serum LDL-C and apoB levels, improve dyslipidemia-injured HDL functions, and reduce oxidative stress, and it may have a beneficial role in prevention of potential metabolic syndrome.
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