期刊
JOURNAL OF LIPID RESEARCH
卷 54, 期 9, 页码 2559-2567出版社
ELSEVIER
DOI: 10.1194/jlr.P036475
关键词
eicosapentaenoic acid; docosahexaenoic acid; fish; meat; plant oils; alcohol; Alzheimer's disease; polyunsaturated fatty acid
资金
- Groupe Lipides et Nutrition
- Fondation pour la Recherche Medicale (FRM)
- Caisse Nationale Maladie des Travailleurs Salaries (CNAMTS)
- Direction Generale de la Sante (DGS)
- Mutuelle Generale de l'Education Nationale (MGEN)
- Institut de la Longevite
- Regional Council of Aquitaine
- Regional Council of Bourgogne
- Fondation de France
- Ministry of Research-INSERM Programme Cohortes et collections de donnees biologiques
- Conseil Regional d'Aquitaine
- ANR-Agence Nationale de la Recherche-The French National Research Agency under the Programme National de Recherche en Alimentation et nutrition humaine [ANR-06-PNRA-005]
- Fondation Plan Alzheimer
- Canada Research Chairs
- FRQS
- NSERC
- Lesieur
- Bausch Lomb
- Aprifel
- Danone Institute
- Jean Mayer Human Nutrition Research Center on Aging
- Tufts University
- Vifor Pharma
- Danone
- Institut Carnot LISA
The main risk factors for Alzheimer's disease, age and the epsilon 4 allele of the APOE gene (APOE4), might modify the metabolism of n-3 PUFAs and in turn, their impact on cognition. The aim of this study was to investigate the association between dietary fat and plasma concentrations of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in elderly persons, taking the APOE4 genotype into account. The sample was composed of 1,135 participants from the Three-City study aged 65 years and over, of whom 19% were APOE4 carriers. Mean plasma proportions of EPA [1.01%, standard deviation (SD) 0.60] and DHA (2.41%, SD 0.81) did not differ according to APOE4. In multivariate models, plasma EPA increased with frequency of fish consumption (P < 0.0001), alcohol intake (P = 0.0006), and female gender (P = 0.02), and decreased with intensive consumption of n-6 oils (P = 0.02). The positive association between fish consumption and plasma DHA was highly significant whatever the APOE genotype (P < 0.0001) but stronger in APOE4 non-carriers than in carriers (P = 0.06 for interaction). Plasma DHA increased significantly with age (P = 0.009) in APOE4 noncarriers only.jlr These findings suggest that dietary habits, gender, and APOE4 genotype should be considered when designing interventions to increase n-3 PUFA blood levels in older people.
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