4.6 Review

The PCSK9 decade

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Hematology

Endogenous Estrogens Lower Plasma PCSK9 and LDL Cholesterol But Not Lp(a) or Bile Acid Synthesis in Women

Lena Persson et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)

Article Cardiac & Cardiovascular Systems

Gene Inactivation of Proprotein Convertase Subtilisin/Kexin Type 9 Reduces Atherosclerosis in Mice

Maxime Denis et al.

CIRCULATION (2012)

Article Biochemistry & Molecular Biology

Increasing Serum Half-life and Extending Cholesterol Lowering in Vivo by Engineering Antibody with pH-sensitive Binding to PCSK9

Javier Chaparro-Riggers et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Cardiac & Cardiovascular Systems

被撤回的出版物: Plasma PCSK9 Levels and Clinical Outcomes in the TNT (Treating to New Targets) Trial (Retracted article. See vol. 61, pg. 1751, 2013)

Roeland Huijgen et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2012)

Article Biotechnology & Applied Microbiology

PCSK9 LNA Antisense Oligonucleotides Induce Sustained Reduction of LDL Cholesterol in Nonhuman Primates

Marie W. Lindholm et al.

MOLECULAR THERAPY (2012)

Review Biotechnology & Applied Microbiology

The biology and therapeutic targeting of the proprotein convertases

Nabil G. Seidah et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Article Medicine, General & Internal

Effect of a Monoclonal Antibody to PCSK9 on LDL Cholesterol

Evan A. Stein et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Biochemistry & Molecular Biology

Removal of acidic residues of the prodomain of PCSK9 increases its activity towards the LDL receptor

Oystein L. Holla et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Biochemistry & Molecular Biology

Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH

Paola Lo Surdo et al.

EMBO REPORTS (2011)

Article Biochemistry & Molecular Biology

In Vivo Evidence That Furin from Hepatocytes Inactivates PCSK9

Rachid Essalmani et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

A Two-step Binding Model of PCSK9 Interaction with the Low Density Lipoprotein Receptor

Taichi Yamamoto et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Novel Domain Interaction Regulates Secretion of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Protein

Fen Du et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo

Yan G. Ni et al.

JOURNAL OF LIPID RESEARCH (2011)

Article Biochemistry & Molecular Biology

Role of the C-terminal domain of PCSK9 in degradation of the LDL receptors

Oystein L. Holla et al.

JOURNAL OF LIPID RESEARCH (2011)

Article Biochemistry & Molecular Biology

PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke

Estelle Rousselet et al.

JOURNAL OF LIPID RESEARCH (2011)

Review Cardiac & Cardiovascular Systems

Proprotein convertase subtilisin/kexin type 9 (PCSK9): From structure-function relation to therapeutic inhibition

G. Tibolla et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2011)

Article Cardiac & Cardiovascular Systems

Serum PCSK9 is associated with multiple metabolic factors in a large Han Chinese population

Qin Cui et al.

ATHEROSCLEROSIS (2010)

Article Biochemistry & Molecular Biology

Effects of the Prosegment and pH on the Activity of PCSK9 EVIDENCE FOR ADDITIONAL PROCESSING EVENTS

Suzanne Benjannet et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

A new method for measurement of total plasma PCSK9: clinical applications

Genevieve Dubuc et al.

JOURNAL OF LIPID RESEARCH (2010)

Article Biochemistry & Molecular Biology

Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans

Jeffrey D. Browning et al.

JOURNAL OF LIPID RESEARCH (2010)

Article Biochemistry & Molecular Biology

PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain

Mali Liu et al.

JOURNAL OF LIPID RESEARCH (2010)

Review Cardiac & Cardiovascular Systems

Molecular basis of PCSK9 function

Gilles Lambert et al.

ATHEROSCLEROSIS (2009)

Article Cardiac & Cardiovascular Systems

Degradation of LDLR protein mediated by 'gain of function' PCSK9 mutants in normal and ARH cells

Tommaso Fasano et al.

ATHEROSCLEROSIS (2009)

Article Biochemistry & Molecular Biology

Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor

Christopher J. Duff et al.

BIOCHEMICAL JOURNAL (2009)

Article Medical Laboratory Technology

Plasma Proprotein Convertase Subtilisin/Kexin Type 9: A Marker of LDL Apolipoprotein B-100 Catabolism?

Dick C. Chan et al.

CLINICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Structural and Biochemical Characterization of the Wild Type PCSK9-EGF(AB) Complex and Natural Familial Hypercholesterolemia Mutants

Matthew J. Bottomley et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells

Markey C. McNutt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Endocrinology & Metabolism

Genetic and Metabolic Determinants of Plasma PCSK9 Levels

Susan G. Lakoski et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)

Article Biochemistry & Molecular Biology

Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice

Yi Luo et al.

JOURNAL OF LIPID RESEARCH (2009)

Article Biochemistry & Molecular Biology

PCSK9: a convertase that coordinates LDL catabolism

Jay D. Horton et al.

JOURNAL OF LIPID RESEARCH (2009)

Editorial Material Pediatrics

Looking Ahead to the Next 75 Years for The Journal of Pediatrics and Medical Publishing

Glen Campbell et al.

JOURNAL OF PEDIATRICS (2009)

Article Multidisciplinary Sciences

A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates

Joyce C. Y. Chan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide

LiXin Shan et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Article Biochemistry & Molecular Biology

Annexin A2 Is a C-terminal PCSK9-binding Protein That Regulates Endogenous Low Density Lipoprotein Receptor Levels

Gaetan Mayer et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Functional analysis of sites within PCSK9 responsible for hypercholesterolemia

Shilpa Pandit et al.

JOURNAL OF LIPID RESEARCH (2008)

Article Biochemistry & Molecular Biology

Plasma PCSK9 preferentially reduces liver LDL receptors in mice

Aldo Grefhorst et al.

JOURNAL OF LIPID RESEARCH (2008)

Article Biochemistry & Molecular Biology

Plasma PCSK9 levels are significantly modified by statins and fibrates in humans

Janice Mayne et al.

LIPIDS IN HEALTH AND DISEASE (2008)

Article Multidisciplinary Sciences

Molecular basis for LDL receptor recognition by PCSK9

Hyock Joo Kwon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor

Da-Wei Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

Maria Frank-Kamenetsky et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9

Holly E. Careskey et al.

JOURNAL OF LIPID RESEARCH (2008)

Article Medical Laboratory Technology

Serum proprotein convertase subtilisin Kexin type 9 is correlated directly with serum LDL cholesterol

William E. Alborn et al.

CLINICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Plasma PCSK9 levels correlate with cholesterol in men but not in women

Janice Mayne et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Biochemistry & Molecular Biology

Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity

Jun Li et al.

BIOCHEMICAL JOURNAL (2007)

Review Biochemistry & Molecular Biology

Versatility in ligand recognition by LDL receptor family proteins: advances and frontiers

Stephen C. Blacklow

CURRENT OPINION IN STRUCTURAL BIOLOGY (2007)

Article Cardiac & Cardiovascular Systems

The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population

Amanda J. Hooper et al.

ATHEROSCLEROSIS (2007)

Article Biochemistry & Molecular Biology

Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells

Markey C. McNutt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation

Timothy S. Fisher et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Biochemistry & Molecular Biology

Unravelling the functional significance of PCSK9

Gilles Lambert

CURRENT OPINION IN LIPIDOLOGY (2007)

Article Biochemistry & Molecular Biology

The crystal structure of PCSK9: A regulator of plasma LDL-cholesterol

Derek E. Piper et al.

STRUCTURE (2007)

Article Biochemistry & Molecular Biology

Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia

David Cunningham et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice

Mark J. Graham et al.

JOURNAL OF LIPID RESEARCH (2007)

Article Medicine, Research & Experimental

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

Thomas A. Lagace et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Medicine, General & Internal

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

JC Cohen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Biochemistry & Molecular Biology

Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c

P Costet et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Genetics & Heredity

Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote

Zhenze Zhao et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2006)

Article Multidisciplinary Sciences

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

S Rashid et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment

KN Maxwell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

KN Maxwell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Multidisciplinary Sciences

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

JD Horton et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Genetics & Heredity

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

M Abifadel et al.

NATURE GENETICS (2003)

Article Multidisciplinary Sciences

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1):: Liver regeneration and neuronal differentiation

NG Seidah et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice

KN Maxwell et al.

JOURNAL OF LIPID RESEARCH (2003)