期刊
JOURNAL OF LIPID RESEARCH
卷 53, 期 8, 页码 1437-1450出版社
ELSEVIER
DOI: 10.1194/jlr.R026682
关键词
bacterial infection; biological function; diabetes; glycolipid; hemostasis; immune system; nervous system; sulfatide; thrombosis; viral infection
资金
- Global COE Program from the Japan Society for the Promotion of Science
- MEXT/JSPS KAKENHI Grant [C
- 23590549]
- Mizutani Foundation for Glycoscience
- Tokyo Biochemical Research Foundation
- Hamamatsu Scientific Research Foundation
- Sasakawa Scientific Research Grant from The Japan Science Society
- Adaptable and Seamless Technology Transfer Program (A-step) through Target-driven RD, JST
- Grants-in-Aid for Scientific Research [23590549] Funding Source: KAKEN
Sulfatide is 3-O-sulfogalactosylceramide that is synthesized by two transferases (ceramide galactosyltransferase and cerebroside sulfotransferase) from ceramide and is specifically degraded by a sulfatase (arylsulfatase A). Sulfatide is a multifunctional molecule for various biological fields including the nervous system, insulin secretion, immune system, hemostasis/thrombosis, bacterial infection, and virus infection. Therefore, abnormal metabolism or expression change of sulfatide could cause various diseases. Here, we discuss the important biological roles of sulfatide in the nervous system, insulin secretion, immune system, hemostasis/thrombosis, cancer, and microbial infections including human immunodeficiency virus and influenza A virus.(jlr) Our review will be helpful to achieve a comprehensive understanding of sulfatide, which serves as a fundamental target of prevention of and therapy for nervous disorders, diabetes mellitus, immunological diseases, cancer, and infectious diseases. Takahashi, T., and T. Suzuki. Role of sulfatide in normal and pathological cells and tissues. J. Lipid Res. 2012. 53: 1437-1450.
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