期刊
JOURNAL OF LIPID RESEARCH
卷 52, 期 7, 页码 1429-1434出版社
ELSEVIER
DOI: 10.1194/jlr.D015255
关键词
atherosclerosis; permeability rate; lipoprotein influx
资金
- Institute of Biomedical Imaging Sciences [IBIS-97708]
- Civilian Research and Development Foundation [RUB1-2932-SR-08]
- National Heart, Lung, and Blood Institute of the National Institutes of Health [T32-HL-07812]
Atherosclerosis is an inflammatory process occurring in arterial tissue, involving the subintimal accumulation of LDL. Measurement of the rate at which LDL and other lipoproteins, such as HDL and VLDL, enter and exit the tissue can provide insight into the mechanisms involved in the development of atherosclerotic lesions. Permeation of VLDL, LDL, HDL, and glucose was measured for both normal and atherosclerotic human carotid endarterectomy tissues (CEA) at 20 degrees C and 37 degrees C using optical coherence tomography (OCT). The rates for LDL permeation through normal CEA tissue were (3.16 +/- 0.37) x 10(-5) cm/s at 20 degrees C and (4.77 +/- 0.48) x 10(-5) cm/s at 37 degrees C, significantly greater (P < 0.05) than the rates for atherosclerotic CEA tissue at these temperatures [(1.97 +/- 0.34) x 10(-5) cm/s at 20 degrees C and (2.01 +/- 0.23) x 10(-5) cm/s at 37 degrees C]. This study effectively used OCT to measure the rates at which naturally occurring lipoproteins enter both normal and diseased carotid intimal tissue.-Ghosn, M. G., M. Mashiatulla, S. H. Syed, M. A. Mohamed, K. V. Larin, and J. D. Morrisett. Permeation of human plasma lipoproteins in human carotid endarterectomy tissues: measurement by optical coherence tomography. J. Lipid Res. 2011. 52: 1429-1434.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据