相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。The Early and Ongoing Experience with the Cholesterol-Fed Rabbit as a Model of Alzheimer's Disease: The Old, the New and the Pilot
D. Larry Sparks
JOURNAL OF ALZHEIMERS DISEASE (2017)
FTY720 Stimulates 27-Hydroxycholesterol Production and Confers Atheroprotective Effects in Human Primary Macrophages
Tomas Blom et al.
CIRCULATION RESEARCH (2010)
Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis
Rebecca Schuele et al.
JOURNAL OF LIPID RESEARCH (2010)
MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 protein
Mark Charman et al.
JOURNAL OF LIPID RESEARCH (2010)
Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression of CYP46A1 gene transcription
Maria Joao Nunes et al.
JOURNAL OF NEUROCHEMISTRY (2010)
Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease
Daniel Ory et al.
MOLECULAR GENETICS AND METABOLISM (2010)
Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease
Eloise Hudry et al.
MOLECULAR THERAPY (2010)
ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD
Elena Y. Bryleva et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol Turnover in the Brain
David W. Russell et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2009)
Transcriptional regulation of cholesterol 24-hydroxylase by histone deacetylase inhibitors
Marjan Shafaati et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Niemann-Pick C2 (NPC2) and intracellular cholesterol trafficking
Judith Storch et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2009)
CYP7B1 mutations in pure and complex forms of hereditary spastic paraplegia type 5
Cyril Goizet et al.
BRAIN (2009)
Activity-Regulated Cytoskeleton-Associated Protein in Rodent Brain is Down-Regulated by High Fat Diet in vivo and by 27-Hydroxycholesterol in vitro
Laura Mateos et al.
BRAIN PATHOLOGY (2009)
Midlife Serum Cholesterol and Increased Risk of Alzheimer's and Vascular Dementia Three Decades Later
Alina Solomon et al.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2009)
Absence of ApoE Upregulates Murine Brain ApoD and ABCA1 Levels, But Does Not Affect Brain Sterol Levels, While Human ApoE3 and Human ApoE4 Upregulate Brain Cholesterol Precursor Levels
Paula J. Jansen et al.
JOURNAL OF ALZHEIMERS DISEASE (2009)
CYP7B1: One Cytochrome P450, Two Human Genetic Diseases, and Multiple Physiological Functions
Ashlee R. Stiles et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors
M. Futter et al.
JOURNAL OF MEDICAL GENETICS (2009)
Two novel CYP7B1 mutations in Italian families with SPG5: a clinical and genetic study
Chiara Criscuolo et al.
JOURNAL OF NEUROLOGY (2009)
Cholesterol Regulates the Endoplasmic Reticulum Exit of the Major Membrane Protein P0 Required for Peripheral Myelin Compaction
Gesine Saher et al.
JOURNAL OF NEUROSCIENCE (2009)
Oxysterols and neurodegenerative diseases
Ingemar Bjorkhem et al.
MOLECULAR ASPECTS OF MEDICINE (2009)
Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on β-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells
Jaya R. P. Prasanthi et al.
MOLECULAR NEURODEGENERATION (2009)
Alzheimer's disease beyond APOE
Michael A. van Es et al.
NATURE GENETICS (2009)
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
Jean-Charles Lambert et al.
NATURE GENETICS (2009)
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
Denise Harold et al.
NATURE GENETICS (2009)
Analysis of CYP7B1 in non-consanguineous cases of hereditary spastic paraplegia
Rebecca Schuele et al.
NEUROGENETICS (2009)
White matter lesions in spastic paraplegia with mutations in SPG5/CYP7B1
Roberta Biancheri et al.
NEUROMUSCULAR DISORDERS (2009)
Chronic Cyclodextrin Treatment of Murine Niemann-Pick C Disease Ameliorates Neuronal Cholesterol and Glycosphingolipid Storage and Disease Progression
Cristin D. Davidson et al.
PLOS ONE (2009)
25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production
David R. Bauman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Statins for the prevention of dementia
Bernadette McGuinness et al.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2009)
Sequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degeneration
Maria K. Tsaousidou et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2008)
Histone deacetylase inhibitors: A new mode for inhibition of cholesterol metabolism
Sridar V. Chittur et al.
BMC GENOMICS (2008)
Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntingtons disease
Valerio Leoni et al.
BRAIN (2008)
Mechanisms of neurodegeneration in Huntington's disease
Joana M. Gil et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2008)
apoE isoform-specific disruption of amyloid β peptide clearance from mouse brain
Rashid Deane et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Neonatal cholestatic liver disease in an Asian patient with a homozygous mutation in the oxysterol 7α-hydroxylase gene
Isao Ueki et al.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2008)
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
Emyr Lloyd-Evans et al.
NATURE MEDICINE (2008)
NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes
Rodney E. Infante et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Purified NPC1 protein - I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein
Rodney E. Infante et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Purified NPC1 protein - II. Localization of sterol binding to a 240-amino acid soluble luminal loop
Rodney E. Infante et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Apolipoprotein E and Alzheimer's disease:: molecular mechanisms and therapeutic opportunities
Angel Cedazo-Minguez
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2007)
Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington's disease
Marta Valenza et al.
NEUROBIOLOGY OF DISEASE (2007)
Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation
Marta Valenza et al.
HUMAN MOLECULAR GENETICS (2007)
Structural basis of sterol binding by NPC2, a lysosomal protein deficient in Niemann-Pick type C2 disease
Sujuan Xu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Amyloid beta as a regulator of lipid homeostasis
Marcus O. W. Grimm et al.
TRENDS IN MOLECULAR MEDICINE (2007)
Regulation of α- and β-secretase activity by oxysterols:: Cerebrosterol stimulates processing of APP via the α-secretase pathway
D. Famer et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
On the mechanism of cerebral accumulation of cholestanol in patients with cerebrotendinous xanthomatosis
Ute Panzenboeck et al.
JOURNAL OF LIPID RESEARCH (2007)
Unique patient with cerebrotendinous xanthomatosis.: Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase
M. Hansson et al.
JOURNAL OF INTERNAL MEDICINE (2007)
Change in MRI striatal volumes as a biomarker in preclinical Huntington's disease
Elizabeth H. Aylward
BRAIN RESEARCH BULLETIN (2007)
Overview: The long and winding road to understanding Alzheimer's disease
Joachim Herz
NEURON (2007)
Survival of adult neurons lacking cholesterol synthesis in vivo
Ursula Fuenfschilling et al.
BMC NEUROSCIENCE (2007)
Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7 alpha-hydroxy-3-oxo-4-cholestenoic acid
Steve Meaney et al.
JOURNAL OF LIPID RESEARCH (2007)
Gene set enrichment analyses revealed several affected pathways in Niemann-Pick disease type C fibroblasts
Aloys De Windt et al.
DNA AND CELL BIOLOGY (2007)
Clues to Neuro-Degeneration in Niemann-Pick Type C Disease from Global Gene Expression Profiling
Jonathan V. Reddy et al.
PLOS ONE (2006)
HE1/NPC2 status in human reproductive tract and ejaculated spermatozoa:: consequence of vasectomy
Christine Legare et al.
MOLECULAR HUMAN REPRODUCTION (2006)
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
Rona K. Graham et al.
CELL (2006)
24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux
K Abildayeva et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes
Alfred Rapp et al.
BIOCHIMIE (2006)
Apolipoprotein E4: A causative factor and therapeutic target in neuropathology including Alzheimer's disease
RW Mahley et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Brain cholesterol turnover required for geranylgeraniol production and learning in mice
TJ Kotti et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1) -: Marked insensitivity toward different regulatory axes
Y Ohyama et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
NPC2 is expressed in human and murine liver and secreted into bile: Potential implications for body cholesterol homeostasis
A Klein et al.
HEPATOLOGY (2006)
Role of cholesterol in amyloid cascade: cholesterol-dependent modulation of tau phosphorylation and mitochondrial function
M. Michikawa
ACTA NEUROLOGICA SCANDINAVICA (2006)
Oxysterols and Alzheimer's disease
I. Bjorkhem et al.
ACTA NEUROLOGICA SCANDINAVICA (2006)
Clinical and molecular diagnosis of cerebrotendinous xanthomatosis with a review of the mutations in the CYP27A1 gene
G. N. Gallus et al.
NEUROLOGICAL SCIENCES (2006)
Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells:: ApoE structure as a potential therapeutic target
SM Ye et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Prevalence and clinical significance of sonographic detection of enlarged regional lymph nodes in Crohn's disease
G Maconi et al.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2005)
Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease
M Valenza et al.
JOURNAL OF NEUROSCIENCE (2005)
Patients with atherosclerosis may have increased circulating levels of 27-hydroxycholesterol and cholestenoic acid
A Babiker et al.
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION (2005)
Crossing the barrier:: net flux of 27-hydroxycholesterol into the human brain
M Heverin et al.
JOURNAL OF LIPID RESEARCH (2005)
Mutation in the sterol 27-hydroxylase gene associated with fatal cholestasis in infancy
S von Bahr et al.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2005)
High cholesterol level is essential for myelin membrane growth
G Saher et al.
NATURE NEUROSCIENCE (2005)
Elevated endosomal cholesterol levels in Niemann-Pick cells inhibit Rab4 and perturb membrane recycling
A Choudhury et al.
MOLECULAR BIOLOGY OF THE CELL (2004)
Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain
N Ohgami et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Differential expression of cholesterol hydroxylases in Alzheimer's disease
J Brown et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Cholesterol metabolism in the central nervous system during early development and in the mature animal
JM Dietschy et al.
JOURNAL OF LIPID RESEARCH (2004)
Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease
M Heverin et al.
JOURNAL OF LIPID RESEARCH (2004)
Consequences of NPC1 and NPC2 loss of function in mammalian neurons
SU Walkley et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2004)
Protein misfolding in neurodegenerative diseases
EI Agorogiannis et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2004)
Brain cholesterol:: Long secret life behind a barrier
I Björkhem et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2004)
APOE genotype effects on Alzheimer's disease onset and epidemiology
JW Ashford
JOURNAL OF MOLECULAR NEUROSCIENCE (2004)
Generation of viable cholesterol-free mice
A Wechsler et al.
SCIENCE (2003)
Feedback regulation of bile acid synthesis in primary human hepatocytes:: Evidence that CDCA is the strongest inhibitor
E Ellis et al.
HEPATOLOGY (2003)
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice
FM Harris et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology
MA Pappolla et al.
NEUROLOGY (2003)
NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols
A Frolov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Spatial and temporal distribution of intracellular free cholesterol in brains of a Niemann-Pick type C mouse model showing hyperphosphorylated tau protein. Implications for Alzheimer's disease
S Treiber-Held et al.
JOURNAL OF PATHOLOGY (2003)
Alzheimer's disease: the cholesterol connection
L Puglielli et al.
NATURE NEUROSCIENCE (2003)
Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors
V Giandomenico et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease
N Friedland et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Dehydroepiandrosterone 7-hydroxylase CYP7B: Predominant expression in primate hippocampus and reduced expression in Alzheimer's disease
JLW Yau et al.
NEUROSCIENCE (2003)
Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes?
FW Pfrieger
BIOESSAYS (2003)
Cholesterol accumulates in cell bodies, but is decreased in distal axons, of Niemann-Pick C1-deficient neurons
B Karten et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Mutations in the sterol 27-hydoxylase gene (CYP27A) cause hepatitis of infancy as well as cerebrotendinous xanthomatosis
PT Clayton et al.
JOURNAL OF INHERITED METABOLIC DISEASE (2002)
Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model -: Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis
K Meir et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses
S Sipione et al.
HUMAN MOLECULAR GENETICS (2002)
Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
J Hardy et al.
SCIENCE (2002)
Oxysterols -: Friends, foes, or just fellow passengers?
I Björkhem et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2002)
The sterol-sensing domain: multiple families, a unique role?
PE Kuwabara et al.
TRENDS IN GENETICS (2002)
Regional and progressive thinning of the cortical ribbon in Huntington's disease
HD Rosas et al.
NEUROLOGY (2002)
Oxysterols induce interleukin-1 beta production in human macrophages
T Rosklint et al.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2002)
Cholesterol and neuropathologic markers of AD - A population-based autopsy study
LJ Launer et al.
NEUROLOGY (2001)
From brain to bile -: Evidence that conjugation and ω-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans
I Björkhem et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons
YD Huang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Midlife vascular risk factors and late-life mild cognitive impairment -: A population-based study
M Kivipelto et al.
NEUROLOGY (2001)
Disturbance of neuronal plasticity is a critical pathogenetic event in Alzheimer's disease
T Arendt
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2001)
Topological analysis of Niemann-Pick C1 protein reveals that the membrane orientation of the putative sterol-sensing domain is identical to those of 3-hydroxy-3-methylglutaryl-CoA reductase and sterol regulatory element binding protein cleavage-activating protein
JP Davies et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
LM Refolo et al.
NEUROBIOLOGY OF DISEASE (2000)
Disruption of the oxysterol 7α-hydroxylase gene in mice
J Li-Hawkins et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Rate of functional decline in Huntington's disease
K Marder et al.
NEUROLOGY (2000)
Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice
I Tesseur et al.
AMERICAN JOURNAL OF PATHOLOGY (2000)