期刊
JOURNAL OF LIPID RESEARCH
卷 51, 期 9, 页码 2489-2503出版社
ELSEVIER
DOI: 10.1194/jlr.R006338
关键词
Alzheimer's disease; cholesterol/metabolism; cholesterol/trafficking; lipoproteins/assembly; nuclear receptors; omega oxidation
资金
- Swedish Research Council
- Swedish Brain Power
- Blanceflor Foundation nee' Bildt
Cholesterol is an essential component of both the peripheral and central nervous systems of mammals. Over the last decade, evidence has accumulated that disturbances in cholesterol metabolism are associated with the development of various neurological conditions. In addition to genetically defined defects in cholesterol synthesis, which will be covered in another review in this Thematic Series, defects in cholesterol metabolism (cerebrotendinous xanthomatosis) and intracellular transport (Niemann Pick Syndrome) lead to neurological disease. A subform of hereditary spastic paresis (type SPG5) and Huntington's disease are neurological diseases with mutations in genes that are of importance for cholesterol metabolism. Neurodegeneration is generally associated with disturbances in cholesterol metabolism, and presence of the E4 isoform of the cholesterol transporter apolipoprotein E as well as hypercholesterolemia are important risk factors for development of Alzheimer's disease. In the present review, we discuss the links between genetic disturbances in cholesterol metabolism and the above neurological disorders. -Bjrkhem, I., V. Leoni, and S. Meaney. Genetic connections between neurological disorders and cholesterol metabolism. J. Lipid Res. 51: 2489-2503.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据