5-Lipoxygenase: mechanisms of regulation

5-Lipoxygenase (5-LO) catalyzes two steps in biosynthesis of leukotrienes (LTs), a group of lipid mediators of inflammation derived from arachidonic acid (AA). LT antagonists are used in treatment of asthma; more recently a potential role also in atherosclerosis has raised considerable interest. Furthermore, possible effects of 5-LO metabolites in relation to tumorigenesis have emerged.jlr Thus, an understanding of the biochemistry of this lipoxygenase has potential implications for treatment of various diseases.-Radmark, O., and B. Samuelsson. 5-Lipoxygenase: mechanisms of regulation. J. Lipid Res. 2009. S40-S45.