期刊
JOURNAL OF LIPID RESEARCH
卷 50, 期 -, 页码 S305-S310出版社
ELSEVIER
DOI: 10.1194/jlr.R800041-JLR200
关键词
phosphatidylethanolamine; cardiolipin; phosphatidylglycerol; lactose permease; membrane domains; topogenesis; lipid genetics
资金
- National Istitutes of Health [GM20478]
- John S. Dunn, Sr. Research Foundation
Lipids fulfill multiple and diverse functions in cells. Establishing the molecular basis for these functions has been challenging due to the lack of catalytic activity of lipids and the pleiotropic effects of mutations that affect lipid composition. By combining molecular genetic manipulation of membrane lipid composition with biochemical characterization of the resulting phenotypes, the molecular details of novel lipid functions have been established. This review summarizes the results of such a combined approach to defining lipid function in bacteria.-Dowhan, W. Molecular genetic approaches to defining lipid function. J. Lipid Res. 2009. S305-S310.
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