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Shilpa Pandit et al.
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Plasma PCSK9 preferentially reduces liver LDL receptors in mice
Aldo Grefhorst et al.
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The self-inhibited structure of full-length PCSK9 at 1.9 Å reveals structural homology with resistin within the C-terminal domain
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The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population
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Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells
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Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation
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Relation of PCSK9 mutations to serum low-density lipoprotein cholesterol in childhood and adulthood (from the bogalusa heart study)
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Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat a of low density lipoprotein receptor decreases receptor recycling and increases degradation
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The crystal structure of PCSK9: A regulator of plasma LDL-cholesterol
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Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice
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Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice
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Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B
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Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy
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Effect of mutations in the PCSK9 gene on the cell surface LDL receptors
J Cameron et al.
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Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
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A spectrum of PCSK9 Alleles contributes to plasma levels of low-density lipoprotein cholesterol
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Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote
Zhenze Zhao et al.
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An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis
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Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9
S Rashid et al.
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Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment
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Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
C Jonathan et al.
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Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia
G Dubuc et al.
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Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver
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NARC-1/PCSK9 and its natural mutants -: Zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol
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Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype
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Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1):: Liver regeneration and neuronal differentiation
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Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice
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