期刊
JOURNAL OF LIPID RESEARCH
卷 50, 期 -, 页码 S277-S281出版社
ELSEVIER
DOI: 10.1194/jlr.R800063-JLR200
关键词
liver X receptors; lipopolysaccharide; low density lipoprotein
资金
- National Institutes of Health [GM069338]
- American Heart Association
Atherosclerosis can be considered as both a chronic inflammatory disease and a lipid metabolism disorder. Innate immunity pathways have long been suspected to contribute to the initiation and progression of atherosclerosis. This suggests that crosstalk between lipid metabolism and innate immunity pathways plays an important role for the development and/or the prevention of atherosclerosis. However, it is not fully defined how innate immunity affects lipid metabolism. Macrophages play a central role in atherogenesis through the accumulation of cholesterol and the production of inflammatory mediators and cytokines. Liver X receptors (LXRs) exert an important atheroprotective effect in the macrophage. In addition to regulating cholesterol metabolism, LXRs are also negative regulators of macrophage inflammatory gene responses. jlr In this review, we will discuss the roles of LXRs in the macrophage as key factors that link innate immunity and lipid metabolism.-Shibata, N., and C. K. Glass. Regulation of macrophage function in inflammation and atherosclerosis. J. Lipid Res. 2009. S277-S281.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据