期刊
JOURNAL OF LIGHTWAVE TECHNOLOGY
卷 29, 期 13, 页码 1926-1930出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JLT.2011.2150734
关键词
Bimodal waveguide; evanescent wave detection; integrated optics; optical biosensors; waveguides
资金
- Fundacion M. Botin from the Spanish Ministry of Industry [TSI-020301-2008-11]
- LEUKEM-CHIP project (Internal program, CIBER-BBN)
The performance of an interferometric device based on integrated Bimodal Waveguides (BiMW) for sensing is demonstrated. The sensors are fabricated using standard silicon technology and can achieve a detection limit of 2.5.10(-7) RIU for homogeneous sensing, rendering in a very high sensitive device. The applicability of the bimodal waveguide interferometer as label-free biosensor has been demonstrated by the real-time monitoring of the biomolecular interaction of BSA and antiBSA. Due to their simplicity, the interferometric devices could be further integrated in complete lab-on-a-chip platforms for point-of-care diagnostics showing them as a powerful instrument for biochemical analysis.
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