期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 97, 期 2, 页码 259-271出版社
WILEY
DOI: 10.1189/jlb.3RU0914-443R
关键词
Th17; intraepithelial lymphocyte; inflammation; multiple sclerosis
资金
- Department of Biotechnology, Government of India [BT/RLF/Re-entry/41/2010, BT/03/IYBA/2010, BT/PR4610/MED/30/720/2012]
gamma delta T cells represent a small population of overall T lymphocytes (0.5-5%) and have variable tissue distribution in the body. gamma delta T cells can perform complex functions, such as immune surveillance, immunoregulation, and effector function, without undergoing clonal expansion. Heterogeneous distribution and anatomic localization of gamma delta T cells in the normal and inflamed tissues play an important role in alloimmunity, autoimmunity, or immunity. The cross-talk between gamma delta T cells and other immune cells and phenotypic and functional plasticity of gamma delta T cells have been given recent attention in the field of immunology. In this review, we discussed the cellular and molecular interaction of gamma delta T cells with other immune cells and its mechanism in the pathogenesis of various autoimmune diseases.
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