期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 94, 期 4, 页码 671-675出版社
OXFORD UNIV PRESS
DOI: 10.1189/jlb.1012540
关键词
chemokines; alarmins; Leishmania; BCG; pDC; cDC
资金
- Swiss National Foundation [310030-129852/1, PDFMP3-129700]
- Swiss National Science Foundation (SNF) [PDFMP3_129700, 310030_129852] Funding Source: Swiss National Science Foundation (SNF)
infection. They migrate to the site of acute infection and also transiently to dLNs. In addition to their well-established role as microbial killers, accumulating evidence shows that neutrophils can play an immunoregulatory role. Neutrophils were recently shown to influence the activation of different leukocyte types including NK cells, B cells, and DCs. DCs are professional APCs playing a key role to the launching and regulation of the immune response; thus, crosstalk between neutrophils and resident or newly recruited DCs may have a direct impact on the development of the antigen-specific immune response and thereby, on the outcome of infection. Neutrophils may regulate DC recruitment and/or activation. We will review here recent progress in the field, including those presented during the first international symposium on Neutrophil in Immunity, held in Quebec, Canada, in June 2012, and discuss how neutrophil regulatory action on DCs may differ depending on the type of invading microorganism and local host factors.
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