期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 93, 期 1, 页码 63-69出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.0512260
关键词
hematopoiesis; dendritic cells; stroma
资金
- National Health and Medical Research Council of Australia [585443]
- Australian National University Graduate School Scholarships
The main DC subsets in murine spleen arise from BM-derived precursors. Recently, a novel APC type was described in spleen. To determine if spleen contains the progenitors of this subset, a stromal coculture system was used to assess candidate progenitors for their hematopoietic potential. Here, the progenitor of that subset is identified as a spleen endogenous Lin(-)c-kit(lo) hematopoietic progenitor and is most highly enriched among the Lin(-)c-kit(lo)CD34(+) subset. Dendritic-like cells produced in vitro functionally resemble the previously described in vivo equivalent subset with high endocytic capacity and capability for antigen-specific activation of CD8(+) T cells but not CD4(+) T cells. J. Leukoc. Biol. 93: 63-69; 2013.
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