期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 94, 期 2, 页码 325-335出版社
OXFORD UNIV PRESS
DOI: 10.1189/jlb.0313128
关键词
class switch; gut-homing molecule; mucosal immunity
资金
- National Research Foundation of Korea (NRF)
- Korean government (MEST) [2010-0012311]
- Brain Korea 21 program
- National Research Foundation of Korea [2010-0012311] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Retinoic acid, in cooperation with TGF-1, increases IgA class switching and expression of gut-homing molecules CCR9 and 47, on mouse B cells. The present study demonstrates that RA has activity of an IgA switch factor and is more specific than TGF-1. RA independently caused only IgA switching, whereas TGF-1 caused IgA and IgG2b switching. We found that RA increased IgA production and that this was a result of its ability to increase the frequency of IgA-secreting B cell clones. Increased IgA production was accompanied by an increase of GLT. RA activity was abrogated by an antagonist of the RAR. Additionally, RA affected intestinal IgA production in mice. Surprisingly, RA, in combination with TGF-1, notably enhanced not only IgA production and GLT expression but also CCR9 and 47 expression on B cells. These results suggest that RA selectively induces IgA isotype switching through RAR and that RA and TGF- have important effects on the overall gut IgA antibody response.
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