期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 92, 期 1, 页码 75-82出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.1011530
关键词
viral; replication; NS1; PB1-F2; TRAIL; ARDS
资金
- Transregional Collaborative Research Center of the German Research Council [SFB-TR84, B2]
- Excellence Cluster Cardio-Pulmonary System (ECCPS)
- FluResearchNet, a nationwide research network on zoonotic influenza
- German Federal Ministry of Research and Education [01 KI 1006C, 01 KI 1006M, 01 KI 1006E, 01 KI 1006A]
- Behring-Rontgen-Stiftung
Programmed cell death is a crucial cellular response frequently observed in IV-infected tissue. This article reviews the current knowledge on the molecular virus-host interactions that induce apoptosis pathways in an IV-infected cell and the functional implications of these cellular signaling events on viral propagation at distinct steps during the viral replication cycle. Furthermore, it summarizes the role of IV-induced apoptosis pathways in equilibrating the host's antiviral immune response between effective viral clearance and development of severe apoptotic lung injury. J. Leukoc. Biol. 92: 75-82; 2012.
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