期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 90, 期 2, 页码 271-284出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.0810457
关键词
membrane traffic; pH; granules; NADPH oxidase; Fc receptors
资金
- Swedish Research Council [2005-6582, 2007-1906]
- Crafoord Foundation
- Greta and Johan Kock Foundation
- Kungliga Fysiografiska Sallskapet
- Thelma Zoega Foundation
- Alfred Osterlund Foundation
The neutrophil is a key player in immunity, and its activities are essential for the resolution of infections. Neutrophil-pathogen interactions usually trigger a large arsenal of antimicrobial measures that leads to the highly efficient killing of pathogens. In neutrophils, the phagocytic process, including the formation and maturation of the phagosome, is in many respects very different from that in other phagocytes. Although the complex mechanisms that coordinate the membrane traffic, oxidative burst, and release of granule contents required for the microbicidal activities of neutrophils are not completely understood, it is evident that they are unique and differ from those in macrophages. Neutrophils exhibit more rapid rates of phagocytosis and higher intensity of oxidative respiratory response than do macrophages. The phagosome maturation pathway in macrophages, which is linked to the endocytic pathway, is replaced in neutrophils by the rapid delivery of preformed granules to nonacidic phagosomes. This review describes the plasticity and dynamics of the phagocytic process with a special focus on neutrophil phagosome maturation. J. Leukoc. Biol. 90: 271-284; 2011.
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