期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 89, 期 6, 页码 837-845出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.1209788
关键词
interleukin; regulatory molecules; antigen-presenting cells; immunoregulation
资金
- Deutsche Forschungsgemeinschaft [SFB 405-B15, B16]
- Helmholtz Alliance against Cancer, The Wilhelm Sander Foundation
IL-27, an IL-12 family member, was initially described as a proinflammatory cytokine. Nevertheless, it also poses anti-inflammatory activity, being involved in suppressing development of TH-17 cells as well as in the induction of inhibitory Tr1 cells. Recent data obtained in mice suggest that it can down-modulate the function of APCs. However, until now, nothing was known about the influence of IL-27 on human DCs. We investigated the effect of IL-27 on in vitro human MoDCs and on ex vivo blood DCs. Our results show that treatment of mDCs with IL-27 led to specific up-regulation of surface expression of several molecules, including B7-H1, in the absence of general DC maturation. Moreover, we demonstrated that IL-27-treated DCs exhibit a reduced capacity to stimulate proliferation and cytokine production of allogeneic T cells as compared with control DCs. Decisively, we identified B7-H1 as a crucial molecule, responsible for suppressive effects of IL-27 DC on T cells. Our data demonstrate for the first time that in addition to the dual role of IL-27 in the modulation of T cell activation and differentiation, human IL-27 modulates an immune response through DCs, i.e., by inducing immunosuppressive B7-H1 molecules and reducing the stimulatory potential of DCs. J. Leukoc. Biol. 89: 837-845; 2011.
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