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CD137 enhances monocyte-ICAM-1 interactions in an E-selectin-dependent manner under flow conditions
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Mice deficient for CD137 ligand are predisposed to develop germinal center-derived B-cell lymphoma
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CD137L-and RANKL-mediated reverse signals inhibit osteoclastogenesis and T lymphocyte proliferation
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Hypercostimulation through 4-1BB Distorts Homeostasis of Immune Cells
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CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice
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Analysis of CD137 and CD137L expression in human primary tumor tissues
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The 4-1BB ligand and 4-1BB expressed on osteoclast precursors enhance RANKL-induced osteoclastogenesis via bi-directional signaling
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EUROPEAN JOURNAL OF IMMUNOLOGY (2008)
CD137 ligand reverse signaling has multiple functions in human dendritic cells during an adaptive immune response
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CD137 induces proliferation of murine hematopoietic progenitor cells and differentiation to macrophages
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Characterisation of soluble murine CD137 and its association with systemic lupus
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Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells
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Induction of proliferation and monocytic differentiation of human CD34+ cells by CD137 ligand signaling
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CD137 ligand prevents the development of T-helper type 2 cell-mediated allergic asthma by interferon-γ-producing CD8+ T cells
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CLINICAL AND EXPERIMENTAL ALLERGY (2007)
Signal transduction mechanisms of CD137 ligand in human monocytes
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Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages
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Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania
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T cell costimulatory and inhibitory receptors as therapeutic targets for inducing anti-tumor immunity
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CURRENT CANCER DRUG TARGETS (2007)
CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity
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Enhanced osteoclastogenesis in 4-1BB-deficient mice caused by reduced interleukin-10
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A signal through 4-1BB ligand inhibits receptor for activation of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis by increasing interferon (IFN)-beta production
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Binding of the intracellular Fas ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL
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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Cotransfection of dendritic cells with RNA coding for HER-2/neu and 4-1BBL increases the induction of tumor antigen specific cytotoxic T lymphocytes
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Infection-induced up-regulation of the costimulatory molecule 4-1BB in osteoblastic cells and its inhibitory effect on M-CSF/RANKL-induced in vitro osteoclastogenesis
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Serum concentrations of soluble 4-1BB and 4-BB ligand correlated with the disease severity in rheumatoid arthritis
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EXPERIMENTAL AND MOLECULAR MEDICINE (2004)
CD137 and CD137 ligand constitutively coexpressed on human T and B leukemia cells signal proliferation and survival
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Ligands working as receptors: reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system
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Lipopolysaccharide preferentially induces 4-1BB ligand expression on human monocyte-derived dendritic cells
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A functional anti-human 4-1BB ligand monoclonal antibody that enhances proliferation of monocytes by reverse signaling of 4-1BBL
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HYBRIDOMA AND HYBRIDOMICS (2003)
Expression of CD137 (4-1BB) on human follicular dendritic cells
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Provision of 4-1BB ligand enhances effector and memory CTL responses generated by immunization with dendritic cells expressing a human tumor-associated antigen
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4-1BB-ligand is regulated on human dendritic cells and induces the production of IL-12
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4-1BB ligand stimulation enhances myeloid dendritic cell maturation from human umbilical cord blood CD34+ progenitor cells
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Immune responses in 4-1BB (CD137)-deficient mice
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Cutting edge: expression of functional CD137 receptor by dendritic cells
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Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells
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Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Eα-transgenic mice
GF Zhu et al.
JOURNAL OF IMMUNOLOGY (2001)
Phenotypic characterization of five dendritic cell subsets in human tonsils
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AMERICAN JOURNAL OF PATHOLOGY (2001)
CD137 expression in tumor vessel walls - High correlation with malignant tumors
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Comparative analysis of CD137 and LPS effects on monocyte activation, survival, and proliferation
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Expression of soluble CD137 correlates with activation-induced cell death of lymphocytes
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