期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 88, 期 3, 页码 507-515出版社
WILEY
DOI: 10.1189/jlb.1109738
关键词
cell activation; antigen presentation
资金
- Roche Organ Transplantation Research Foundation (ROTRF)
- European FP6 Grant RISET Reprogramming the Immune System for Establishment of Tolerance
- association Vaincre la Mucoviscidose
- Ministere de l'Enseignement Superieur et de la Recherche
- MRC [G1000215] Funding Source: UKRI
- Medical Research Council [G1000215] Funding Source: researchfish
DCs play a central role in the development of innate and adaptive immunity but also in the induction and maintenance of immune tolerance. Identification of factors that govern DC activation, their maturation state, and their capacity to induce proinflammatory or tolerogeneic responses therefore represents a crucial aim of research. We previously identified a new molecule, Tmem176B (which we named TORID initially), as highly expressed in a model of allograft tolerance in the rat. We showed that its overexpression in rat DCs blocked their maturation, suggesting a role for this molecule in the maturation process. To characterize the function of Tmem176B further, we used a split-ubiquitin yeast, twohybrid system to identify interacting partners and found that Tmem176B associated with itself but also with Tmem176A, a membrane protein similar to Tmem176B. Interestingly, these two molecules showed similar mRNA expression patterns among various murine tissues and immune cells and were both down-regulated following DC maturation. In addition, we showed that in using RNAi, these molecules are both involved in the maintenance of the immature state of the DCs. Taken together, these data suggest that Tmem176B and Tmem176A associate to form multimers and restrain DC maturation. Therefore, these two molecules may represent valid targets to regulate DC function. J. Leukoc. Biol. 88: 507- 515; 2010.
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