期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 87, 期 6, 页码 1001-1009出版社
WILEY
DOI: 10.1189/jlb.0809542
关键词
dendritic cells; monocytes; macrophages; T cells
资金
- NIA NIH HHS [P30 AG024824, R01 AG028268, R01 AG020628, R56 AG020628, P30 AG013283] Funding Source: Medline
Aging is associated with a progressive dysregulation of immune responses. Whether these changes are solely responsible for the observed increased mortality and morbidity amongst the elderly is uncertain. Recent advances have highlighted the age-associated changes that occur beyond T and B lymphocytes. Additionally, multiple human and animal studies have identified a relationship between chronic low-grade inflammation and geriatric syndromes, such as frailty, suggesting that the phenomenon of inflamm-aging may provide a rationale for the increased vulnerability to chronic inflammatory diseases in older adults. In the present review, we broadly summarize our current understanding of age-dependent changes in leukocyte function and their contribution to aging-related disease processes. J. Leukoc. Biol. 87: 1001-1009; 2010.
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