期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 86, 期 5, 页码 1065-1073出版社
WILEY
DOI: 10.1189/jlb.0609385
关键词
microenvironment; metastasis; angiogenesis; myeloid cells
资金
- Associazione Italiana Ricerca sul Cancro (AIRC), Italy
- Ministry of Health and Istituto Superiore Sanita Italy
The microenvironment of solid tumors is characterized by a reactive stroma with an abundance of inflammatory mediators and leukocytes, dysregulated vessels and proteolytic enzymes. TAM, major players in the connection between inflammation and cancer, summarize a number of functions (e. g., promotion of tumor cell proliferation and angiogenesis, incessant matrix turnover, repression of adaptive immunity), which ultimately have an important impact on disease progression. Thus, together with other myeloid-related cells present at the tumor site (Tie2 macrophages and MDSCs), TAM represent an attractive target of novel biological therapies of tumors. J. Leukoc. Biol. 86: 1065-1073; 2009.
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