期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 86, 期 5, 页码 1119-1124出版社
WILEY
DOI: 10.1189/jlb.0209117
关键词
signaling cascade; integrins; P-selectin glycoprotein ligand 1
资金
- Deutsche Forschungsgemeinschaft [428/3-1]
Cell-cell interactions mediating leukocyte recruitment and inflammation are crucial for host defense. Leukocyte recruitment into injured tissue proceeds in a multi-step process. The first contact of leukocytes with endothelial cells (capturing or tethering) is mediated by selectins and their counter-receptor P-selectin glycoprotein ligand (PSGL)-1. During capture and rolling, leukocytes collect different inflammatory signals, which can activate various pathways. Integration of these signals leads to leukocyte activation, integrin-mediated arrest, cytoskeleton rearrangement, polarization, and transmigration. PSGL-1 on leukocytes also binds to activated platelets, where P-selectin is expressed at locally high site densities following alpha-granule fusion with the plasma membrane. Here, we review the signaling functions of PSGL-1 and speculate how the different known signaling events might relate to different phases of leukocyte recruitment. J. Leukoc. Biol. 86: 1119-1124; 2009.
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