期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 87, 期 4, 页码 671-682出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.0709505
关键词
chemokine receptor; peritoneal cavity; homeostatic; recirculation; exit signal
资金
- German Research Foundation (DFG) [SFB 633]
T and B lymphocytes recirculate among blood, lymph, and extralymphoid tissues to ensure immune surveillance and the establishment of self-tolerance. The underlying mechanisms regulating homeostatic lymphocyte recirculation through body cavities are not fully understood. Here, we demonstrate that the homeostatic chemokine receptor CCR7 regulates homeostatic recirculation of lymphocytes through body cavities. CCR7 deficiency results in massive accumulation of CD4(+) and CD8(+) T cells and B-2 B cells in the peritoneal and pleural cavities. The increase in B-2 B and T lymphocytes is not associated with an altered maturation and/or activation status of these cells. Mechanistically, an increase in peritoneal lymphocyte numbers is caused by impaired egress of CCR7-deficient lymphocytes from body cavities. These results establish that CCR7 plays a crucial role in lymphocyte exit from the PerC. J. Leukoc. Biol. 87: 671-682; 2010.
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