期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 87, 期 2, 页码 257-263出版社
WILEY
DOI: 10.1189/jlb.0409221
关键词
IFN-gamma; CTL
资金
- National Institutes of Health-National Cancer Institute [R01 CA104645]
- Alliance Foundation of Roswell Park
The presence of IL-12 during antigen stimulation instructs naive CD8+ T cells for long-term effector responses, but their mechanisms of collaboration are not understood completely. Herein, we report that CD8+ T cells (OT-I T cells) stimulated with antigen for a longer duration show enhanced sensitization to IL-12 as a result of Erk1/2-dependent, increased Ets-1 phosphorylation and subsequent increases in IL-12R beta 2 expression. Correspondingly, naive OT-I T cells stimulated by antigen for a longer duration in the presence of IL-12, irrespective of frequency of APCs, show robust effector maturation and mount long-term antigen-recall responses upon adoptive transfer. These results identify the role of antigen strength-dependent Erk1/2 activation for Ets-1-mediated collaboration with IL-12 in CD8+ T cells. J. Leukoc. Biol. 87: 257-263; 2010.
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