期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 85, 期 1, 页码 29-33出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.0708415
关键词
transforming growth factor-beta; immune regulation; latent-associated
资金
- NEI NIH HHS [R01 EY010752, R01 EY010752-13] Funding Source: Medline
- NATIONAL EYE INSTITUTE [R01EY010752] Funding Source: NIH RePORTER
The evolutionarily conserved TGF-beta proteins are distributed ubiquitously throughout the body and have a role in almost every biological process. In immunity, TGF-beta has an important role in modulating immunity. Much is understood about the process of TGF-beta production as a latent molecule and of the consequences and the intercellular signaling of active TGF-beta binding to its receptors; however, there is little discussed between the production and activation of TGF-beta. This review focuses on what is understood about the biochemical and physiological processes of TGF-beta activation and identifies the gaps in understanding immune cell activation of TGF-beta. A mechanistic understanding of the process activating TGF-beta can lead to regulating multiple biological systems by enhancing or inhibiting TGF-beta activation. J. Leukoc. Biol. 85: 29-33; 2009.
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