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Deficiency in NOD antigen-presenting cell function may be responsible for suboptimal CD4+ CD25+ T-cell-mediated regulation and type 1 diabetes development in NOD mice
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Intranasal vaccination with proinsulin DNA induces regulatory CD4+ T cells that prevent experimental autoimmune diabetes
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GAD65-and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects
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Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope
SC Kent et al.
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Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
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Single cell analysis shows decreasing FoxP3 and TGFβ1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes
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Naturally arising Foxp3-expressing CD25+ CD4+ regulatory T cells in immunological tolerance to self and non-self
S Sakaguchi
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Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
R Setoguchi et al.
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Definition of target antigens for naturally occurring CD4+ CD25+ regulatory T cells
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The role of regulatory T lymphocytes in asthma pathogenesis
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Regulatory T cell lineage specification by the forkhead transcription factor FoxP3
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Increased CD40 ligand and platelet-monocyte aggregates in patients with type 1 diabetes mellitus
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The role of CD40-CD154 interactions in autoimmunity and the benefit of disrupting this pathway
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Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells
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Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
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T cells recognize multiple GAD65 and proinsulin Epitopes in human type 1 diabetes, suggesting determinant spreading
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Cooperative roles of CTLA-4 and regulatory T cells in tolerance to an islet cell antigen
MP Eggena et al.
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Peripheral CD4loCD40+ auto-aggressive T cell expansion during insulin-dependent diabetes mellitus
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Human CD25+ regulatory T cells:: two subsets defined by the integrins α4β7 or α4β1 confer distinct suppressive properties upon CD4+ T helper cells
M Stassen et al.
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Enhanced levels of CD154 (CD40 ligand) on platelets in patients with chronic heart failure
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Cutting edge: CD40-induced expression of recombination activating gene (RAG) 1 and RAG2: A mechanism for the generation of autoaggressive T cells in the periphery'
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Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells
CT Moses et al.
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The Subpopulation of CD4+ CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7
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Expression of CD40 identifies a unique pathogenic T cell population in type 1 diabetes
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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
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Characterization of peripheral regulatory CD4(+) T cells that prevent diabetes onset in nonobese diabetic mice
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