期刊
JOURNAL OF LARYNGOLOGY AND OTOLOGY
卷 123, 期 1, 页码 54-60出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0022215108003770
关键词
Sensorineural Hearing Loss; Sudden Hearing Loss; Ozone
Objective: To investigate the safety and efficacy of ozone therapy in adult patients with sudden sensorineural hearing loss. Design: Prospective, randomised, double-blinded, placebo-controlled, parallel group, clinical trial. Subjects: Forty-five adult patients presented with sudden sensorineural hearing loss, and were randomly allocated to receive either placebo (15 patients) or ozone therapy (auto-haemotherapy; 30 patients). For the latter treatment, 100 ml of the patient's blood was treated immediately with a 1:1 volume, gaseous mixture of oxygen and ozone (from an ozone generator) and re-injected into the patient by intravenous infusion. Treatments were administered twice weekly for 10 sessions. The following data were recorded: pre- and post-treatment mean hearing gains; air and bone pure tone averages; speech reception thresholds; speech discrimination scores; and subjective recovery rates. Results: Significant recovery was observed in 23 patients (77 per cent) receiving ozone treatment, compared with six (40 per cent) patients receiving placebo (p < 0.05). Mean hearing gains, pure tone averages, speech reception thresholds and subjective recovery rates were significantly better in ozone-treated patients compared with placebo-treated patients (p < 0.05). Conclusion: Ozone therapy is a significant modality for treatment of sudden sensorineural hearing loss; no complications were observed.
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