期刊
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
卷 56, 期 6, 页码 313-316出版社
WILEY-BLACKWELL
DOI: 10.1002/jlcr.3024
关键词
apoptosis imaging; phosphonium salts; fluoride; automated synthesis
资金
- BBSRC
- GSK
- Imanova
A novel phosphonium salt bearing a fluorine-18 labelled triazole has been designed as a potential imaging agent for apoptosis. The radiosynthesis of [1-(2-[18F]fluoroethyl),1H[1,2,3]triazole 4-ethylene] triphenylphosphonium bromide ([18F]MitoPhos_01) has been carried out on a fully automated system in a two-step reaction. Radiolabelling an ethyl azide and then carrying out a copper-mediated 1,3-cycloaddition reaction has allowed for total synthesis time to be slightly more than 1h from aqueous [18F]fluoride. After purification by HPLC, the average radiochemical yield was determined to be 9% (not decay corrected); the specific activity was on average 70GBq/mu mol at the end of synthesis, and the radiochemical purity was >99%.
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