Radiosynthesis of tritium-labeled novel nitromethylene neonicotinoids compounds with NaB3H4

Paichongding and Cycloxaprid are two novel neonicotinoids with good industrialization prospects for their high activity against imidacloprid-resistant pest. In this paper, the radiosynthesis of [H-3(2)]-Paichongding and [H-3(2)]-Cycloxaprid was achieved using a (NaBH4)-H-3 reduction. The title compounds were obtained with chemical purities of 98.7 and 98.4%, and radiochemical purities of 97.3 and 98.6%, respectively. The labeled compounds could be used as radiotracers for further study of metabolism and toxicology.