期刊
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
卷 53, 期 7-8, 页码 548-551出版社
WILEY-BLACKWELL
DOI: 10.1002/jlcr.1779
关键词
[C-11]benzyl acetate; carbon-11; [C-11]carbon monoxide; carbonylation; PET
资金
- National Institutes of Health (National Institute of Mental Health) [Z01-MH-002793, Z01-MH-002795]
[carbonyl-C-11]Benzyl acetate ([C-11]1) has been proposed as a potential agent for imaging glial metabolism of acetate to glutamate and glutamine with positron emission tomography. [C-11]1 was synthesized from [C-11]carbon monoxide, iodomethane and benzyl alcohol via palladium-mediated chemistry. The radiosynthesis was automated with a modified Synthia platform controlled with in-house developed Labview software. Under production conditions, [C-11]1 was obtained in 10% (n = 6) decay-corrected radiochemical yield from [C-11]carbon monoxide in >96% radiochemical purity and with an average specific radioactivity of 2415 mCi/mu mol. The total radiosynthesis time was about 45 min. Peak uptake of radioactivity in monkey brain (SW = 3.1) was relatively high and may be amenable to measuring uptake and metabolism of acetate in glial cells of the brain.
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