期刊
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
卷 52, 期 7-8, 页码 286-288出版社
WILEY-BLACKWELL
DOI: 10.1002/jlcr.1599
关键词
[F-18]FDOPA; electrophilic fluorodestannylation; [F-18]F-2; Freon-11
资金
- Academy of Finland [116084]
- University of Turku Foundation
- Academy of Finland (AKA) [116084, 116084] Funding Source: Academy of Finland (AKA)
Owing to the ozone layer-depleting properties of chlorofluorocarbon compounds, alternative solvents for electrophilic fluorination reactions are desirable. Chloroform, dichloromethane, acetone or their deuterated analogues were examined as substitutes for Freon-11 in the electrophilic synthesis of 6-[F-18]fluoro-L-DOPA ([F-18]FDOPA). CDCl3, CD2Cl2 and C3D6O were found to be suitable solvents in this reaction, with the deuterated solvents providing significantly higher yields than Freon-11. There were no differences among the solvents in the specific radioactivity, the radiochemical purity, the chemical purity or the microbiological quality of the final product. However, the radiochemical yield of [F-18]FDOPA was increased when acetic acid was added to the precursor solution prior to the fluorination reaction.
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