期刊
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
卷 51, 期 1-2, 页码 109-112出版社
WILEY
DOI: 10.1002/jlcr.1493
关键词
synthesis; 6 beta-([1-C-14] propoxy)celangulin V; celangulin V; insecticide
Chinese bittersweet, Celastrus angulatus Max., is a widely distributed plant and is used as a traditional insecticide in China. Celangulin V (CA-V), one of the main insecticidal ingredients from the plant, has special insecticidal mechanism. A synthesized compound, 6 beta-propoxycelangulin V, exhibits more remarkable insecticidal activity against insect pests. In this study, the synthesis of a labeled version of a CAN analog, 6 beta-([1-C-14]propoxy)celangulin V, was accomplished from 1-[1-C-14] propanol and CAN in two steps with the chemical and radiochemical purities of 98.7 and 99.9%, respectively. The labeled compound can be used as a radiotracer to study the mechanism of action of CAN analogs.
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