期刊
JOURNAL OF KOREAN MEDICAL SCIENCE
卷 25, 期 6, 页码 980-983出版社
KOREAN ACAD MEDICAL SCIENCES
DOI: 10.3346/jkms.2010.25.6.980
关键词
Ultraviolet Rays; Fatty Acids, Nonesterified; Fatty Acids, Omega-3; 11,14,17-eicosatrienoic acid; Phospholipases A(2), Calcium-Independent; Human Elongase 1
资金
- Ministry of Health & Welfare, the Republic of Korea [A060160]
- AMOREPACIFIC Corporation
- Korea Health Promotion Institute [A060160] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We investigated the alterations of major fatty acid components in epidermis by natural aging and photoaging processes, and by acute ultraviolet (UV) irradiation in human skin. Interestingly, we found that 11,14,17-eicosatrienoic acid (ETA), which is one of the omega-3 polyunsaturated acids, was significantly increased in photoaged human epidermis in vivo and also in the acutely UV-irradiated human skin in vivo, while it was significantly decreased in intrinsically aged human epidermis. The increased ETA content in the epidermis of photoaged human skin and acute UV-irradiated human skin is associated with enhanced expression of human elongase 1 and calcium-independent phophodiesterase A(2). We demonstrated that ETA inhibited matrix metalloproteinase (MMP)-1 expression after UV-irradiation, and that inhibition of ETA synthesis using EPTC and NA-TCA, which are elongase inhibitors, increased MMP-1 expression. Therefore, our results suggest that the UV increases the ETA levels, which may have a photoprotective effect in the human skin.
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