期刊
JOURNAL OF KOREAN MEDICAL SCIENCE
卷 25, 期 7, 页码 1011-1016出版社
KOREAN ACAD MEDICAL SCIENCES
DOI: 10.3346/jkms.2010.25.7.1011
关键词
cholangiocarcinoma; Clonorchis sinensis; Korea
资金
- National Cancer Center [NCC-0710040, NCC-0710160, NCC-0410130, NCC-0710140]
In 2009, infection with the liver fluke Clonorchis sinensis (C. sinensis) was classified as carcinogenic to humans (Group 1) based on its involvement in the etiology of cholangiocarcinoma by the International Agency for Research on Cancer. However, little is known about the descriptive epidemiology of cholangiocarcinoma in Korea. We examined incidence trends of intrahepatic and extrahepatic cholangiocarcinomas, using data from the Korea National Cancer Incidence database for 1999-2005. The prevalence of C. sinensis infection was estimated from a recent population-based survey in rural endemic areas. Cholangiocarcinoma incidence rates are currently rising, even while primary liver cancer incidence rates are decreasing. Annual percent changes in cholangiocarcinoma incidence rates were 8% for males and 11% in females. Known areas of C. sinensis endemicity showed high incidence rates of cholangiocarcinoma. The positivity of C. sinensis eggs in stool samples from endemic areas was more than 25% of adults tested during 2005-2008. From a meta-analysis, the summary odds ratio for cholangiocarcinoma due to C. sinensis infection was 4.7 (95% confidence interval: 2.2-9.8). Approximately 10% of cholangiocarcinomas in Korea were caused by chronic C. sinensis infections. More specific policies, including health education and an extensive effort for early detection in endemic areas, are needed.
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