期刊
JOURNAL OF KOREAN MEDICAL SCIENCE
卷 24, 期 5, 页码 867-873出版社
KOREAN ACAD MEDICAL SCIENCES
DOI: 10.3346/jkms.2009.24.5.867
关键词
Premenopausal Women; Isoflavones; Equol; Genistein; Bone Turnover; Estrogen Antagonists
资金
- Korea Healthcare Technology R&D Project, Ministry of Health Welfare and Family Affairs, Republic of Korea [A060030]
- Korea Health Promotion Institute [A060030] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Soy-isoflavones may act as estrogenic agonists or antagonists depending on the endogenous hormone status. These clinical effects can be exerted variably in individuals by the metabolic ability to produce a more potent metabolite than precursors. The objective of this randomized, double-blind, placebo-controlled study was to investigate the skeletal effect of isoflavones according to their metabolic variability in premenopausal women. Volunteers were randomly assigned to receive either soy-extract isoflavones (n=32) or lactose (n=21) once a day for three menstrual cycles. After intervention, the urinary excretions of isoflavones and their metabolites were significantly higher in the soy group than in the placebo group and showed a large inter-individual variation. Women in the soy group were divided into subgroups according to their ability to excrete more potent metabolites. Serum osteocalcin and urine deoxypyridinoline showed a tendency to increase after a challenge in equol high-excretors. Serum osteocalcin concentration in the genistein high-excretors increased significantly after a challenge (P=0.04) but did not increase in either the placebo or genistein low-excretors. An estrogenic antagonistic effect of isoflavones on bone turnover was observed in premenopausal women who are able to produce more potent metabolites.
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