期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 134, 期 2, 页码 415-422出版社
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2013.315
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- Wilhelm-Sander-Stiftung [2008.064.1]
The c-Rel protein, a member of the NF-kappa B transcription factor family, exerts unique and distinctive functions in various cell types. Although c-Rel is expressed in human epidermis, its functions in keratinocytes are poorly understood. Our small interfering RNA based approach of c-Rel silencing in HaCaT keratinocytes induced altered cell morphology toward a spindle-shaped appearance. In addition, c-Rel downregulation resulted in increased apoptosis and significantly reduced proliferation towing to G2/M cell cycle delay, concomitant aberrant mitotic spindle formation, and induction of phospho-aurora A(Thr288). The relevance of c-Rel in epithelial carcinogenesis was further supported by detection of c-Rel expression in squamous cell carcinomas of the skin. Our studies indicate that c-Rel is a key regulator of cell fate decisions in keratinocytes such as cell growth and death and may have a role in epidermal carcinogenesis.
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