期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 132, 期 9, 页码 2131-2133出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/jid.2012.246
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资金
- NIAMS NIH HHS [R01 AR019098, R01 AR061106] Funding Source: Medline
The stratum corneum (SC) extracellular matrix (ECM) is enriched in lipids that are organized into lamellar bilayers, whose molecular architecture is now known. Although these bilayers are important for the permeability barrier, the ECM contains not only lipids but also enzymes, structural proteins, and antimicrobial peptides that impact barrier function. Yet, how such diverse components affect barrier function remains largely unknown. Static models of the epidermis may not do justice to the ECM, which is metabolically active, as it changes both structure and function as it transits to the surface.
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