期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 132, 期 3, 页码 650-657出版社
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2011.374
关键词
-
类别
资金
- NIAID-DAIT
- Atopic Dermatitis and Vaccinia Network NIH/NIAID [HHSN266200400029C, HHSN266200400033C]
- Mary Beryl Patch Turnbull Scholar Program
Interferon regulatory factor 2 (IRF2) is a member of a family of transcriptional factors involved in the modulation of IFN-induced immune responses to viral infection. To test whether genetic variants in IRF2 predict risk of atopic dermatitis (AD) and ADEH (atopic dermatitis complicated by eczema herpeticum), we genotyped 78 IRF2 tagging single-nucleotide polymorphisms (SNPs) in both European-American (n=435) and African-American (n=339) populations. Significant associations were observed between AD and two SNPs (rs793814, P=0.007, odds ratio (OR)=0.52; rs3756094, P=0.037, OR=0.66) among European Americans and one SNP (rs3775572, P=0.016, OR=0.46) among African Americans. Significant associations were also observed between ADEH and five SNPs (P=0.049-0.022) among European Americans. The association with ADEH was further strengthened by haplotype analyses, wherein a five-SNP (CAGGA) haplotype showed the strongest association with ADEH (P=0.0008). Eight IRF2 SNPs were significantly associated with IFN-gamma production after herpes simplex virus (HSV) stimulation (P=0.048-0.0008), including an AD-associated SNP (rs13139310, P=0.008). Our findings suggest that distinct markers in IRF2 may be associated with AD and ADEH, which may depend upon ethnic ancestry, and genetic variants in IRF2 may contribute to an abnormal immune response to HSV.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据