期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 131, 期 3, 页码 565-571出版社
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2010.388
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资金
- United States Department of Health and Human Services, NIH/NIAMS
- Thomas Jefferson University
- Dermatology Foundation
- University of Virginia
Heritable skin diseases represent a broad spectrum of clinical manifestations due to mutations in similar to 500 different genes. A number of model systems have been developed to advance our understanding of the pathomechanisms of genodermatoses. Zebrafish ( Danio rerio), a freshwater vertebrate, has a well-characterized genome, the expression of which can be easily manipulated. The larvae develop rapidly, with all major organs having developed by 5-6 days post-fertilization, including the skin, consisting of the epidermis comprising two cell layers and separated from the dermal collagenous matrix by a basement membrane. This perspective highlights the morphological and ultrastructural features of zebrafish skin, in the context of cutaneous gene expression. These observations suggest that zebrafish provide a useful model system to study the molecular aspects of skin development, as well as the pathogenesis and treatment of select heritable skin diseases.
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